As they celebrate the 110th anniversary of the Pure Food and Drug Act of 1906, which first regulated safety and labeling in the US, six former Commissioners of the Food and Drug Administration (FDA) meet to talk about an agency with wide-ranging regulatory responsibilities. FDA has authority over many foods and virtually all drugs, devices, cosmetics, veterinary products, and tobacco, giving it jurisdiction over one in every four dollars the American consumer spends. What challenges does FDA face in its next 110 years? Does it have the resources and talent to do its job?